TABLE 2.
Main Effects of COMT Val158Met Genotype on WAIS-R Subscale Scores
| WAIS-R subscale | < 13 years of education. N = 230 | ≥ 13 years of education. N = 96 | ||||||
|---|---|---|---|---|---|---|---|---|
| N | Val/Val 123 | Val/Met 94 | Met/Met 14 | F,(df) P value | Val/Val 44 | Val/Met 40 | Met/Met 12 | F, (df) P value |
| Inf | 6.9 | 7.4 | 8.1 | 8.0 | 9.0 | 9.3 | F = 5.9, (5) | |
| (1.9) | (1.8) | (1.5) | - | (2.1) | (2.0) | (1.9) | P = 0.004 | |
| *F = 11.6, (4) | ||||||||
| *P = 0.001 | ||||||||
| Dsp | 7.7 | 7.8 | 8.9 | 9.1 | 9.8 | 8.2 | F = 2.5 (3) | |
| (2.3) | (2.5) | (2.2) | - | (2.2) | (2.4) | (2.9) | P = 0.083 | |
| PC | 8.3 | 9.4 | 9.3 | F = 4.7, (3) | 9.3 | 9.5 | 10.6 | |
| (2.1) | (2.2) | (1.9) | P = 0.010 | (2.3) | (2.4) | (3.0) | - | |
| *F = 9.4 (2) | ||||||||
| *P = 0.003 | ||||||||
| BD | 10.0 | 9.4 | 10.0 | F = 2.3 (6) | 10.6 | 11.4 | 11.2 | |
| (3.0) | (2.3) | (2.4) | P = 0.10 | (3.1) | (3.0) | (3.4) | - | |
ANOVA P values ≤ 0.10 are given here.
F and p values are for COMT genotype effects
Inf = Information; Dsp = Digit Span; Ar = Arithmetic; PC = Picture Completion; BD = Block Design. Digit Symbol, Similarities and Arithmetic were not included since there were no significant or even trend effects.
*
Results are for COMT Val/Val vs [Val/Met + Met/Met]