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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Cancer Res. 2008 May 15;68(10):3579–3583. doi: 10.1158/0008-5472.CAN-07-5533

Figure1.

Figure1

Gadd45a and p21 are not effectors of the p53-dependent apopotic response to oncogenic stress. Brain sections from 3 or more mice of each genotype were analyzed by TUNEL. Average apoptotic indexes (AI) and standard deviations were calculated as described in Materials and Methods. Inactivation of either gadd45a or p21 does not significantly affect p53-dependent apoptosis; deficiency in both effectors causes a small but statistically significant increase of apoptosis, potentially due to relaxation of feedback regulation (P<0.05).