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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Cancer Res. 2008 May 15;68(10):3579–3583. doi: 10.1158/0008-5472.CAN-07-5533

Figure 4.

Figure 4

Gadd45a inactivation extended survival from brain tumors in IR treated TgT121 mice. (A) Survival of TgT121;gadd45a+/+ mice and TgT121;gadd45a−/− mice without IR treatment. Kaplan Meier curves showed a shorter survival of TgT121;gadd45a−/− mice (t50 =207 days, n=45) than TgT121;gadd45a+/+ mice (t50=263 days n=60). (p<0.05, log-rank test). (B) After sub-lethal IR treatment to the head (see Methods), TgT121; gadd45a−/− mice had a better survival (t50=285 days, n=7) than TgT121; gadd45a+/+ mice (t50=223days, n=18) (log rank test, p<0.05).