Table 1.

Experimentally derived relative molar response factors and modified DNA base content in MCF-10A cells prior to doxorubicin exposure

DNA base	Ion used	RMRF	Modified DNA base level (nM/mg DNA)*	Modified DNA base level (modified bases/106 bases)†
5-OH-5-MeHyd	331	0.51±0.05	0.887±0.971	284.±311
5-OH-Hyd	317	-	0.527±0.492	169±157
5-OH-Ura	329	0.61±0.05	0.253±0.243	81.0±77.8
5-OH-Cyt	328	0.65±0.16	0.407±0.255	130±81.6
Thy Gly	259	0.36±0.05	0.608±0.493	194±158
5, 6diOH-Ura	417	4.58±0.44	1.16±1.14	371±365
FapyAde	354	2.02±0.06	1.28±0.539	410±172
8-OH-Ade	352	0.88±0.21	2.13±0.1.49	682±477
Xan	353	0.70±0.27	16.8±5.55	5376±1776
2-OH-Ade	352	0.29±0.08	0.509±0.379	163±121
FapyGua	442	8.09±1.82	7.62±4.88	2438±1562
8-OH-Gua	440	15.84±4.86	38.5±18.0	12320±5760

^*Mean ± SD.

^†1 nmole modified base/mg DNA is 320 molecules of modified base/10⁶DNA bases.