Table 2.
Modified DNA base content in MCF-10A cells cultured for up to 96 hours with 0.1 μM doxorubicin
| DNA base | 0 h | 24 h | 48 h | 72 h | 96 h |
|---|---|---|---|---|---|
| 5OH-5-MeHyd | 1 | 1.72±0.44 | 2.24±0.88 | 2.24±0.49* | 2.45±0.10* |
| 5-OH-Hyd | 1 | 1.58±0.45 | 1.94±0.72 | 2.14±0.59 | 2.36±0.50* |
| 5-OH-Ura | 1 | 1.36±0.29 | 1.82±0.27* | 2.21±0.30* | 2.21±0.20* |
| 5-OH-Cyt | 1 | 1.29±0.3 | 1.34±0.08* | 1.88±0.25* | 1.56±0.24 |
| Thy Gly | 1 | 1.48±0.31 | 1.14±0.19 | 2.00±0.09* | 3.08±1.39 |
| 5,6diOH-Ura | 1 | 1.63±0.36 | 1.65±0.26 | 2.22±0.48* | 1.73±0.06* |
| FapyAde | 1 | 1.28±0.17 | 1.44±0.43 | 1.65±0.45 | 1.46±0.31 |
| 8-OH-Ade | 1 | 1.55±0.41 | 1.69±0.26* | 2.10±0.43* | 1.87±0.40 |
| Xan | 1 | 1.71±0.43 | 2.05±0.10* | 2.48±0.80 | 2.59±0.74 |
| 2-OH-Ade | 1 | 1.49±0.09* | 1.34±0.36 | 1.84±0.55 | 2.15±0.37* |
| FapyGua | 1 | 1.33±0.12* | 1.23±0.22 | 1.68±0.20* | 2.27±0.62* |
| 8-OH-Gua | 1 | 1.10±0.29 | 1.11±0.22 | 1.80±0.16* | 1.96±0.45 |
*
P < 0.05 versus control DNA.