Table 1.
Associations between rubella virus-specific T cell (ELISPOT) responses and HLA haplotypes.
| ELISPOT/HLA locus | Haplotype | Frequency | Test statistic (haplotype t-statistic) | Allele p-value | Global p-value |
|---|---|---|---|---|---|
| IFN-γ ELISPOT | |||||
| Class I | A-C-B | 0.559 | |||
| *02-*07-*07 | 0.034 | 1.82 | 0.069 | ||
| *11-*04-*35 | 0.011 | 1.85 | 0.064 | ||
| Class II | DRB1-DQA1-DQB1-DPA1-DPB1 | 0.666 | |||
| *13-*01-*06-*01-*03 | 0.013 | −2.30 | 0.022 | ||
| IL-10 ELISPOT | |||||
| Class I | A-C-B | 0.248 | |||
| *02-*03-*40 | 0.033 | 1.64 | 0.101 | ||
| Class II | DRB1-DQA1-DQB1-DPA1-DPB1 | 0.722 | |||
| *03-*05-*02-*01-*04 | 0.048 | −2.78 | 0.006 | ||
| *03-*05-*02-*02-*01 | 0.037 | −1.87 | 0.063 | ||
| *13-*01-*06-*01-*03 | 0.013 | 1.87 | 0.062 | ||
Only haplotypes with estimated frequencies ≥0.01 and p-values ≤0.10 are presented. Haplotype effects estimated using a haplotype t-statistic that assesses associations of cytokine ELISPOT levels across haplotypes. Allele p-value compares haplotype of interest to all other haplotypes combined. Statistically significant findings (p < 0.05) are bolded. Analyses adjust for age at blood draw, gender, race, age at first rubella vaccine, age at second rubella vaccine, and cohort status.