Table 2.
Associations between rubella virus-specific Th1 (IFN-γ, IL-2 and IL-12p40) cytokine responses with HLA II haplotypes.
| Cytokine/HLA locus | Haplotype | Frequency | Test statistic (haplotype t-statistic) | Allele p-value | Global p-value |
|---|---|---|---|---|---|
| IFN-γ | |||||
| Class I | A-C-B | 0.305 | |||
| *02-*07-*07 | 0.034 | 2.10 | 0.036 | ||
| *03-*04-*35 | 0.016 | 2.31 | 0.021 | ||
| Class II | DRB1-DQA1-DQB1-DPA1-DPB1 | 0.895 | |||
| *03-*05-*02-*01-*03 | 0.014 | 2.26 | 0.024 | ||
| *04-*03-*03-*01-*03 | 0.020 | 1.94 | 0.053 | ||
| *11-*05-*03-*01-*04 | 0.041 | −1.69 | 0.092 | ||
| *13-*01-*06-*01-*04 | 0.041 | −1.93 | 0.054 | ||
| IL-2 | |||||
| Class I | A-C-B | 0.356 | |||
| *11-*04-*35 | 0.011 | 2.20 | 0.028 | ||
| Class II | DRB1-DQA1-DQB1-DPA1-DPB1 | 0.091 | |||
| *04-*03-*03-*01-*02 | 0.016 | 2.86 | 0.004 | ||
| *04-*03-*03-*01-*04 | 0.098 | 3.06 | 0.002 | ||
| *07-*02-*02-*01-*04 | 0.026 | 1.82 | 0.069 | ||
| *13-*01-*06-*01-*03 | 0.013 | −1.98 | 0.049 | ||
| IL-12p40 | |||||
| Class I | A-C-B | 0.026 | |||
| *02-*03-*40 | 0.033 | −2.20 | 0.028 | ||
| *03-*03-*40 | 0.013 | 2.94 | 0.003 | ||
| *03-*07-*07 | 0.059 | 2.14 | 0.033 | ||
| Class II | DRB1-DQA1-DQB1-DPA1-DPB1 | 0.371 | |||
| *03-*05-*02-*02-*01 | 0.037 | −1.78 | 0.075 | ||
| *07-*02-*03-*01-*04 | 0.014 | 2.27 | 0.024 | ||
| *11-*05-*03-*01-*04 | 0.041 | 1.85 | 0.065 | ||
Only haplotypes with estimated frequencies ≥0.01 and p-values ≤0.10 are presented. Haplotype effects estimated using a haplotype t-statistic that assesses associations of cytokine levels across haplotypes. Allele p-value compares haplotype of interest to all other haplotypes combined. Statistically significant findings (p < 0.05) are bolded. Analyses adjust for age at blood draw, gender, race, age at first rubella vaccine, age at second rubella vaccine, and cohort status.