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. Author manuscript; available in PMC: 2010 May 26.
Published in final edited form as: Vaccine. 2009 Feb 5;27(25-26):3349–3358. doi: 10.1016/j.vaccine.2009.01.080

Table 4.

Associations of rubella virus-specific innate/proinflammatory (TNF-α, GM-CSF and IL-6) cytokine responses with HLA haplotypes.

Cytokine/HLA locus Haplotype Frequency Test statistic (haplotype t-statistic) Allele p-value Global p-value
TNF-α
Class I A-C-B 0.231
*24-*07-*07 0.017 1.78 0.075
*29-*16-*44 0.022 2.38 0.017
Class II DRB1-DQA1-DQB1-DPA1-DPB1 0.547
*07-*02-*03-*01-*04 0.014 −1.65 0.100
*11-*05-*03-*01-*04 0.041 −1.83 0.067
*13-*01-*06-*01-*03 0.013 1.90 0.057
GM-CSF
 Class I A-C-B 0.823
 Class II DRB1-DQA1-DQB1-DPA1-DPB1 0.968
IL-6
Class I A-C-B 0.270
*01-*06-*57 0.011 −1.94 0.053
*24-*07-*07 0.017 2.58 0.010
Class II DRB1-DQA1-DQB1-DPA1-DPB1 0.916
*03-*05-*02-*01-*04 0.048 −2.20 0.028

Only haplotypes with estimated frequencies ≥0.01 and p-values ≤0.10 are presented. Haplotype effects estimated using a haplotype t-statistic that assesses associations of cytokine levels across haplotypes. Allele p-value compares haplotype of interest to all other haplotypes combined. Statistically significant findings (p < 0.05) are bolded. Analyses adjust for age at blood draw, gender, race, age at first rubella vaccine, age at second rubella vaccine, and cohort status.