Table 6.

HLA class I supertype associations with rubella virus-induced Th1 (IFN-γ, IL-2 and IL-12p40) cytokine immune responses.

Cytokine/HLA locus	HLA supertype	Number of alleles	Median secretion value (pg/ml)	Lower Quartile, Q1 (pg/ml)	Upper Quartile, Q3 (pg/ml)	p-value^a	Global p-value^a
IFN-γ	Overall	1426	8.53	2.97	23.41
Class IA							0.865
	A1	330				0.334
	A2	433				0.370
	A3	398				0.948
	A24	183				0.961
	Other^b	82				0.952
Class IB							0.881
	B7	417				0.369
	B27	154				0.785
	B44	370				0.520
	B58	51				0.436
	B62	159				0.619
	Other^b	275				0.846
IL-2	Overall	1426	17.59	7.73	30.48
Class IA							0.203
	A1	330				0.226
	A2	433				0.427
	A3	398	18.92	8.42	31.40	0.017
	A24	183				0.718
	Other^b	82				0.686
Class IB							0.557
	B7	417				0.378
	B27	154				0.553
	B44	370				0.537
	B58	51				0.418
	B62	159				0.164
	Other^b	275				0.535
IL-12p40	Overall	1422	0.00	−7.15	7.17
Class IA							0.633
	A1	329				0.656
	A2	432				0.752
	A3	396				0.644
	A24	183				0.111
	Other^b	82				0.964
Class IB							0.593
	B7	415				0.148
	B27	154				0.628
	B44	369				0.889
	B58	51				0.567
	B62	159				0.778
	Other^b	274				0.149

Q1 and Q3 represent the first (25th percentile) and third (75th percentile) quartiles, respectively. Statistically significant findings (p < 0.05) are bolded.

Linear regression analysis. p-values for cytokine levels were based on inverse cumulative normal transformation. Analyses adjust for age at blood draw, gender, race, age at first rubella vaccine, age at second rubella vaccine, and cohort status.

“Other” includes the following HLA-A alleles: *0217, *0302, *2407, *2608, *2901, *2902, *3004, *3206, *3303, *3401, *6601, *6803, *7401; HLA-B alleles: *0706, *0714, *0801, *1507, *1511, *1522, *1525, *1801, *1803, *1813, *3504, * 3508, *3511, *3512, *3523, *3542, *3906, *4002, *4102, *4201, *4427, *4404, *4405, *4701, *4803, *5703, respectively.