Table 7.

HLA class I supertype associations with rubella virus-induced Th2 (IL-4, IL-5 and IL-10) cytokine immune responses.

Cytokine/HLA locus	HLA supertype	Number of alleles	Median secretion value (pg/ml)	Lower Quartile, Q1 (pg/ml)	Upper Quartile, Q3 (pg/ml)	p-value^a	Global p-value^a
IL-4	Overall	1382	0.30	−0.31	0.96
Class IA							0.971
	A1	317				0.831
	A2	424				0.817
	A3	386				0.862
	A24	177				0.816
	Other^b	78				0.531
Class IB							0.868
	B7	402				0.765
	B27	151				0.419
	B44	356				0.554
	B58	50				0.473
	B62	156				0.491
	Other^b	267				0.994
IL-5	Overall	1382	0.47	0.00	1.09
Class IA							0.261
	A1	317				0.573
	A2	424				0.290
	A3	386	0.45	0.00	0.95	0.060
	A24	177				0.190
	Other^b	78				0.531
Class IB							0.550
	B7	402				0.384
	B27	151				0.110
	B44	356				0.440
	B58	50				0.459
	B62	156				0.834
	Other^b	267				0.687
IL-10	Overall	1426	4.20	2.29	6.69
Class IA							0.140
	A1	330				0.115
	A2	433				0.874
	A3	398	4.01	1.91	6.60	0.022
	A24	183				0.532
	Other^b	82				0.309
Class IB							0.575
	B7	417				0.859
	B27	154				0.634
	B44	370				0.323
	B58	51				0.897
	B62	159	4.13	2.44	6.17	0.079
	Other^b	275				0.821

Q1 and Q3 represent the first (25th percentile) and third (75th percentile) quartiles, respectively. Statistically significant finding (p < 0.05) is bolded.

Linear regression analysis. p-values for cytokine levels were based on inverse cumulative normal transformation. Analyses adjust for age at blood draw, gender, race, age at first rubella vaccine, age at second rubella vaccine, and cohort status.

“Other” includes the following HLA-A alleles: *0217, *0302, *2407, *2608, *2901, *2902, *3004, *3206, *3303, *3401, *6601, *6803, *7401; HLA-B alleles: *0706, *0714, *0801, *1507, *1511, *1522, *1525, *1801, *1803, *1813, *3504, * 3508, *3511, *3512, *3523, *3542, *3906, *4002, *4102, *4201, *4427, *4404, *4405, *4701, *4803, *5703, respectively.