Table 1.
Experimental and theoretical cross-sections for WT Aβ(21-30) and its mutant forms. Theoretical cross-sections are given for the central structure of the most populated cluster (see Table 2 for spread of values).
| Mutant | Charge (pH 7) |
Cross Sections (Å2) |
||
|---|---|---|---|---|
| Experimental* | Theoretical** | % Deviation | ||
| WT | -1 | 227 | 231 | 1.73% |
| D23N | 0 | 222.5 | 220 | 1.12% |
| E22G | 0 | 210 | 208 | 0.95% |
| E22K | +1 | 230 | 224 | 2.61% |
| E22Q | 0 | 226 | 225 | 0.44% |
| S26I | -1 | 229 | 233 | 1.75% |
| D23G | 0 | 216 | 217 | 0.46% |
*
Experimental cross sections correspond to the protein at pH 7. For proteins with a neutral charge, cross sections were taken for the +1 and -1 charge states and averaged.
**
Theoretical cross sections correspond to the protein at pH 7.