Skip to main content
. 2009 Feb 25;29(8):2611–2625. doi: 10.1523/JNEUROSCI.3670-08.2009

Figure 4.

Figure 4.

Differential effects of DRK reduction on 90 min memory. Mean performance indices and SEMs (PI ± SEM) are shown for the indicated genotypes. A, Abrogating DRK in the MBs impairs 90 min memory. Initial training with 8 CS/US produced equal immediate performance between control animals and animals expressing drkRNAi (F(2,15) = 1.761, p > 0.2), n = 5. ANOVA for 90 min memory of the training revealed significant effects of genotype (F(2,50) = 13.490, p < 0.0001). n ≥ 15. B, Training RNAi transgene expressing animals with increased number of pairings does not improve the memory impairment, revealing a specific effect of DRK abrogation in the MBs on memory. Learning was equal between under-trained controls (6 pairings) and drkR-2 expressing animals trained with 8 CS/US. (F(2,12) = 0.029, p > 0.86, n = 6). In contrast, 90 min memory remained impaired in RNAi-expressing flies compared with under-trained controls (F(1,46) = 18.057, p < 0.0001, n ≥20). C, The 90 min memory impairment remained unaltered by more intensive training of drkΔP24/+ heterozygotes indicating a memory specific impairment. ANOVA did not reveal differences between undertrained controls and drkΔP24/+ heterozygotes trained with eight pairings (F(1,12) = 2.327, p > 0.16, n = 6). Ninety-minute memory was significantly impaired in drkΔP24/+ flies compared with under-trained controls (F(1,16) = 5.978, p < 0.05, n ≥7).