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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Cell Immunol. 2009 Apr 5;258(1):18–28. doi: 10.1016/j.cellimm.2009.03.007

Figure 2. Ibuprofen inhibits PGE2 synthesis in human PBMC in a concentration-dependent manner.

Figure 2

Human PBMCs were stimulated with anti-IgM plus CpG 2395 for 2 days. Cells were exposed to increasing concentrations of ibuprofen from 15 µM to 100 µM. Ibuprofen was added at the onset of culture. Control cells received only the vehicle (DMSO). There is a concentration-dependent decrease in PGE2 synthesis. PGE2 production was significantly inhibited by 50 µM ibuprofen (~ 300 pg/ml) and further decreased by 100 µM ( ~100 pg/ml). Data are shown as mean ± SD (n=3). *, p< 0.05, **, p< 0.001 were calculated using one-way ANOVA test followed by Tukey’s post-hoc test.