Skip to main content
. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Cell Immunol. 2009 Apr 5;258(1):18–28. doi: 10.1016/j.cellimm.2009.03.007

Figure 5. Time course of ibuprofen addition and inhibition of antibody synthesis.

Figure 5

PBMC were stimulated with anti-IgM plus CpG 2395 for 7 days in the presence or absence of ibuprofen (added on different days). Panel A and panel B show that only one dose of ibuprofen added at the beginning (day 1) or end of culture (day 7) does not affect IgM or IgG synthesis. Panel C and Panel D show that daily doses of ibuprofen (50 µM) caused a ~ 4 fold decrease in IgM and completely abrogated IgG synthesis. Two doses of ibuprofen decreased IgM and IgG production to the same extent as three doses. *, p< 0.05, **, p< 0.001 were calculated using one-way ANOVA test followed by Tukey’s post-hoc test.