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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Cell Immunol. 2009 Apr 5;258(1):18–28. doi: 10.1016/j.cellimm.2009.03.007

Figure 6. Ibuprofen decreases the number of antibody producing cells.

Figure 6

PBMC were stimulated with anti-IgM plus CpG 2395 for 7 days in the presence or absence of ibuprofen (50 µM; added everyday). Panel A and panel B show that ibuprofen reduced the numbers of antibody secreting cells. In panels C the number of spots was counted and their means +/− SD were plotted on the graph. There are more IgM-producing cells (~ 30 cells / 105 PBMC) compared to IgG (~18 cells/ 105 PBMC). In the presence of ibuprofen there are fewer IgM (~ 15 cells / 105 PBMC) and IgG (~ 3 cells/ 105 PBMC) producing cells. *, p< 0.05 was calculated using one-way ANOVA test followed by Tukey’s post-hoc test.