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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Cell Immunol. 2009 Apr 5;258(1):18–28. doi: 10.1016/j.cellimm.2009.03.007

Figure 7. Ibuprofen inhibits antibody synthesis in purified human B lymphocytes.

Figure 7

Human B lymphocytes were stimulated with anti-IgM (2 µg/ml) plus CpG 2395 (1 µg/ml). Cells were exposed to ibuprofen (50 µM; added on various days of culture). Control cells (no drug) received only the vehicle (DMSO). IgG and IgM synthesis was determined on day 7 of culture. There is a decrease in IgM (panel A) and IgG (panel B) synthesis in B lymphocytes exposed to ibuprofen everyday or on the first days of culture (days 1+2+3). Ibuprofen added on the last days of culture (days 4+5+6) did not reach statistical significance. **, p< 0.001 (as determined by one-way ANOVA test followed by Tukey’s post-hoc test).