Figure 6.
LSD1 knockdown enhances inflammatory gene expression in nondiabetic db/+ MVSMCs. A, Western blotting of db/+ MVSMC cell lysates transfected with siNeg or siLSD1 with indicated antibodies. B through E, db/+ MVSMCs were transfected with siNeg or siLSD1, and expression of MCP-1 (B and C) and IL-6 (D and E) was determined in total RNA isolated from basal or TNF-α–stimulated cells (10 ng/mL for 1 hour) (means±SEM). *P<0.02, **P<0.01 vs siNeg (n=3).