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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Curr Opin Genet Dev. 2007 Jul 6;17(4):309–313. doi: 10.1016/j.gde.2007.05.001

Figure 3. IPC Sorting and Apoptosis.

Figure 3

IPCs are marked in beige, and PPs and cone cells are marked in blue. Roughest protein is indicated by brown lines in IPCs while Hibris protein is indicated by green lines in cones and PPs. (A) At 10 hours pupal life, low uniform levels of Roughest in IPCs result in uniform contact between cells. (B) At 30 hours pupal life, heterophilic interaction between Hibris and Roughest (thick green and brown lines) along IPC:PP contacts result in sorting such that the size of IPC:IPC contacts is reduced in favour of IPC:PP contacts. (C) One IPC establishes contact with a third PP and becomes (D) a TP cell. The other two competing IPCs then must compete for a SP cell fate. Some IPCs which fail to outcompete undergo apoptosis (circles). Figure is modeled after [12].