TABLE 2.
Baseline and Post-Treatment Neuropsychological Test Scoresa Within Each Cognitive Domain
| Celecoxib (n = 22), Mean (SD) |
Placebo (n = 18), Mean (SD) |
||||
|---|---|---|---|---|---|
| Domain | Test | Baseline | Post-Treatment | Baseline | Post-Treatment |
| Psychomotor speed | Trailmaking A | 32.4 (12.9) | 30.7 (9.7) | 29.5 (9.3) | 28.3 (9.0) |
| WAIS-III digit symbol | 70.3 (15.7) | 69.0 (17.8) | 72.1 (17.1) | 74.0 (18.4) | |
| Visuospatial functioning | WAIS-III block design | 37.0 (9.8) | 40.4 (7.5) | 41.1 (11.5) | 41.1 (12.7) |
| Complex figure, copy | 30.4 (4.0) | 30.8 (3.3) | 31.8 (2.8) | 30.6 (2.9) | |
| Executive functioningb | Trailmaking B | 80.3 (34.1) | 78.4 (43.3) | 65.6 (22.2) | 71.2 (37.5) |
| Stroop interference | 127.2 (30.1) | 121.0 (30.5) | 122.9 (36.8) | 125.4 (46.6) | |
| F.A.S. letter fluency | 38.4 (13.6) | 40.9 (14.3) | 41.9 (17.6) | 44.2 (18.7) | |
| Learning | Selective reminding, total recall | 102.6 (13.5) | 103.9 (18.0) | 106.9 (20.8) | 111.6 (19.0) |
| Verbal paired associations I | 17.6 (7.6) | 20.6 (8.0) | 19.5 (9.0) | 21.5 (8.6) | |
| Benton visual retention | 3.9 (1.9) | 4.3 (2.0) | 3.9 (2.5) | 4.7 (3.6) | |
| Delayed recall | Selective reminding, delayed recall | 7.9 (3.0) | 8.3 (2.7) | 9.2 (3.6) | 9.8 (2.7) |
| Complex figure, recall | 15.8 (6.9) | 17.3 (7.7) | 17.3 (7.7) | 16.8 (7.5) | |
| Verbal paired associations II | 6.4 (1.7) | 6.6 (2.1) | 6.2 (2.3) | 7.3 (2.6) | |
| Language/semantic memoryc | Boston naming | 54.9 (3.5) | 55.5 (3.6) | 55.9 (4.3) | 55.7 (5.5) |
| Animal naming | 21.5 (5.7) | 22.5 (4.6) | 20.8 (5.0) | 19.4 (6.1) | |
a
Higher scores indicate better cognitive performance except for Trailmaking A and B, Stroop interference, and Benton Visual Retention, wherein lower scores indicate better performance.
b
F[1,30] = 5.06, p = 0.03.
c
F[1,31] = 6.19, p = 0.02.