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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Annu Rev Microbiol. 2006;60:503–531. doi: 10.1146/annurev.micro.60.080805.142205

Figure 1.

Figure 1

Key steps in RNA silencing. RNA silencing starts with dicing of dsRNA or pre-miRNAs. The resulting small RNAs are incorporated into distinct RISC complexes to direct chromatin modification, translational arrest, and mRNA cleavage. In organisms with RDR, secondary siRNA is synthesized from cleavage products. FX represents host factor implicated in stabilizing cleavage products similar to SGS3 (149). Dashed arrow represents cell-to-cell movement of 21 siRNAs and the potential long-distance movement of 24-nt siRNAs.