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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Mar 10;1792(6):555–563. doi: 10.1016/j.bbadis.2009.02.014

Fig. 3. Forebrain toxicity in induced transgenic mice expressing cyPrP.

Fig. 3

Pregnant mice and pups were supplied with Dox food until 6 weeks of age and then switched to normal food to induce transgene expression in double transgenic mice (tTA+/−; pBI-cyPrP-Gal +/−). Among 11 double transgenic mice, 8 mice were from line 33 and 5 mice were from line 5. Single transgenic littermates (tTA−/−; pBI-cyPrP-Gal+/−) that went through the same induction regime were used as controls. (A) Picture and score of tail suspension test. Error bars represent standard error and the differences are statistically significant, p<0.05 at 2 weeks and p<0.01 at remaining time points. (B) Total locomotor activity as indicated by the number of beam breaks. (C) Scores of tail and toe pinch. (D) The brain and body weight of induced heterozygous double transgenic mice and their single transgenic littermates. (E) A representative pair of double transgenic mouse (Tg(+/−)) and single transgenic littermate (control) showing the difference in the cortex thickness. Bars represent 1 mm.