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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Gastroenterology. 2009 Mar 18;136(7):2356–2364. doi: 10.1053/j.gastro.2009.03.003

Figure 8. Working model of cyclooxygenase pathways and hepatocyte engraftment in the liver.

Figure 8

Cell transplantation induced hepatic expression of PTGS1, PTGS2, and other genes, although prostanoid limbs represented by TXA2 and PGE2 did not regulate cell engraftment. The studies showed that naproxen and celecoxib affected native liver cells, including HSC. Hepatic expression of pleiotropic factors, such as HGF and VEGF, which are both capable of cytoprotection, as well as of genes regulating extracellular matrix (ECM) remodeling provide relevant mechanisms to improve survival and engraftment of transplanted cells.