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. 2009 May 13;6:44. doi: 10.1186/1742-4690-6-44

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Copyright © 2009 Feng et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Synergistic inhibition of HIV-1 replication by combinations of (A) TFV+FTC, (B) TFV+EFV, and (C) FTC+EFV analyzed by MacSynegy II. Calculated additive antiviral interactions were subtracted from experimentally determined values to reveal regions and corresponding concentrations at which synergistic antiviral interactions occurred. Peaks of statistically significant (95% confidence level) synergy are shown in colors from dark blue to red, with red indicating the strongest synergy. Values used to describe the percentage of inhibition above the expected were derived from five experiments.