Table 3.
Analyses of TFV-DP, FTC-TP and EFV combination studies in the HIV-1 RT enzymatic assaya.
| Analysis Methods | Drug Combinations | ||
| TFV-DP+FTC-TP | TFV-DP+EFV | FTC-TP+EFV | |
| Median-effect (CI value) |
synergya (0.47 ± 0.09) |
moderate synergy (0.75 ± 0.04) | moderate synergy (0.70 ± 0.03) |
| MacSynergy IIb (synergy/antagonism volume) |
additive (0.63 ± 1.2/-2.7 ± 3.4) |
minor synergy (44 ± 20/0 ± 0) |
minor synergy (41 ± 15/-0.5 ± 1.1) |
| Isobologram (ADAc, p value) |
synergy (-0.43, 0.001) |
synergy (-0.20, 0.001) |
synergy (-0.14, 0.002) |
| Berenbaum Combination Indices | synergy | NDd | ND |
| Yonetani-Theorell Plots | synergy | synergy | synergy |
a Definition for degree of synergy (whenever applicable) is described in Methods.
b The volumes are calculated at the 95% confidence interval. The values are averages from 3 to 4 independent measurements. Five parallel repeats were tested in each measurement.
c ADA = average deviation from additivity
d ND = not determined.