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Sequence motifs of representative DNA and RNA MTases; bold face residues are conserved in subfamilies. TrmA is m5U54 tRNA MTase of E. coli. Fmu-ecoli, Fmu-bacsu, and Fmu-haein are Fmu proteins from E. coli, Bacillus subtilis, and Haemophilus influenzae, respectively. Met2-ecoli and mtbf-bacsu are two DNA m5C MTases from E. coli and B. subtilis.
