Table 3.
MIC values for individual antibiotics alone (as determined by the broth microdilution method) and in effective synergistic combination with tigecycline (as determined by the chequerboard method) for seven A. baumannii isolates
MIC (mg/L) a | |||||||||
Study code | TIG | LVX | AMK | IPM | CS | TIG/LVX | TIG/AMK | TIG/IPM | TIG/CS |
5 | 4 | 16 | 64 | 16 | 0.25 | 0.25/4 | NS | NS | NS |
11 | 4 | 16 | 64 | 16 | 0.5 | 0.25/4 | 1/16 | NS | NS |
16 | 8 | 16 | 128 | 16 | 0.125 | 2/4 | NS | NS | 2/0.03 |
62 | 4 | 8 | 2 | 2 | 0.25 | NS | NS | 0.25/0.5 | NS |
71 | 4 | 8 | 256 | 16 | 0.5 | NS | 1/64 | NS | NS |
75 | 4 | 16 | 128 | 2 | 0.5 | 0.25/4 | NS | NS | 1/0.125 |
80 | 4 | 8 | 128 | 32 | 0.25 | NS | NS | 0.25/8 | NS |
a Breakpoint criteria are provided in Additional file 1.