Fig. 1.

The effect of minoxidil plus ATRA on hair growth in vitro. Hair follicle organ culture was performed in triplicates with hair follicles obtained from the occipital scalp of three volunteers. Hair growth is enhanced by minoxidil at 1 µM. Minoxidil plus ATRA promotes hair growth more significantly, especially at a concentration of 1 µM minoxidil and 1 nM ATRA. Moreover, the increase in hair growth was significant compared with minoxidil alone. Values were obtained after cumulative growth of 15 hair follicles per each growth condition for 12 days and shown as the means±SEM. ^*, p<0.05; ^†, p<0.01.