Figure 8. SPR sensorgram comparison of the kinetics of binding between Dpl with either recombinant full-length PrP (PrP(23–230)) or truncated PrP (PrP(89–230)).

Equimolar amounts of PrP(23–230) and PrP(89–230) were injected over Dpl-coupled sensor chip, and kinetics of binding was monitored as response units (RU, y axis) on time (seconds, x axis). Full-length PrP(23–230) proved to possess higher binding capability for Dpl than truncated PrP(89–230). The sensorgrams in the figure were obtained with injection of 800 nM of both PrP(23–230) and PrP(89–230).