Table 5.
Probability ratios for the combinations of ALDH2, ADH2 and CYP2E1 genotypes and the amount of alcohol consumed, n (%)
| Alcohol drinking | Genotype | Cases (n = 80) | Controls (n = 480) | OR (95% CI) | OR (95% CI) |
| ALDH2 | |||||
| Never/rare | 1/1 | 7 (8.8) | 72 (15.0) | 1 | |
| -to-light | 1/2 | 7 (8.8) | 180 (37.5) | 0.56 (0.20-1.59) | |
| 2/2 | 0 (0.0) | 33 (6.9) | 0.00 (NC) | ||
| Moderate | 1/1 | 30 (37.5) | 180 (37.5) | 2.29 (0.94-5.57) | |
| -to-heavy | 1/2 | 36 (45.0) | 15 (3.1) | 8.58 (3.28-22.68) | 3.12 (1.86-6.58) |
| ADH1B | |||||
| Never/rare | 1/2+2/2 | 13 (16.3) | 273 (56.9) | 1 | |
| -to-light | 1/1 | 1 (1.3) | 12 (2.5) | 1.00 (0.18-9.22) | |
| Moderate | 1/2+2/2 | 50 (62.5) | 183 (38.1) | 4.75 (2.53-9.38) | |
| -to-heavy | 1/1 | 16 (20.0) | 12 (2.5) | 27.12 (8.52-70.19) | 5.48 (1.98-14.55) |
| CYP2E1 | |||||
| Never/rare | 5 (6.3) | 189 (39.4) | 1 | ||
| -to-light | c1/c1 | 9 (11.3) | 96 (20.0) | 0.56 (0.20-1.59) | |
| Moderate | c1/c2+ | 18 (22.5) | 96 (20.0) | 1.93 (0.43-2.41) | |
| -to-heavy | c2/c2 | ||||
| c1/c1 | 48 (60.0) | 99 (20.6) | 7.64 (2.82-11.31) | 5.32 (1.62-9.28) |