Table 1.
Effects of genotype and treatment for control behavioral measures on test 1 and 2. Motor behavior (open field entries), coordination (rotorod fall latency) and pain threshold responses (tail flick latency) of bigenic APPswe+PSEN1e9 mice and their wildtype counterparts administered vehicle or P4 via subcutaneous pellets (values are mean ± SEM)
| Total open field entries | Rotorod fall latency (s) | Tail flick latency (s) | ||||
|---|---|---|---|---|---|---|
| Condition | Test 1 | Test 2 | Test 1 | Test 2 | Test 1 | Test 2 |
| Wildtype vehicle | 91 ± 12 | 60 ± 11 | 5 ± 1 | 16 ± 11 | 6 ± 1 | 6 ± 1 |
| Wildtype P4 | 53 ± 14* | 75 ± 13* | 30 ± 16 | 16 ± 11 | 9 ± 1 | 7 ± 1 |
| APPswe+PSEN1 vehicle | 116 ± 43 | 103 ± 18 | 51 ± 33 | 8 ± 3 | 8 ± 1 | 7 ± 1 |
| APPswe+PSEN1 P4 | 54 ± 11* | 46 ± 16* | 7 ± 3 | 31 ± 24 | 8 ± 1 | 8 ± 1 |
*P < 0.05 (vs vehicle condition)