Table 4.

Toxicology studies of orpiment, realgar and arsenolite/arsenic trioxide

Arsenicals	Acute Toxicity	Chronic Toxicity	Comments
Orpiment	N/A	Negative in micronucleus assay	High As levels in blood
		Negative in lung tumor formation
Reaglar	N/A	Cutaneous manifestations	Adverse effects
		Mild GI discomfort in chemotherapy	Tolerable
		Prolonged QT, dose-dependent	Tolerable
		Fatty liver, but no liver fibrosis	Long-term exposure
Arsenic trioxide	Sudden death, poisoning	Cardiac effects and GI effects	Chelation effective
		Skin and GI effects	Tolerable
		No secondary cancer reports