Table 2.

Unadjusted and Adjusted Associations between Sample Characteristics and Depressed Mood

Symptom	Unadjusted OR (95% CI)	Adjusted OR (95% CI)*
Hot flashes (past 30 days)
No	1.00 (referent)	1.00 (referent)
Yes	1.73 (1.20, 2.50)	1.48 (1.0, 2.19)
Wake up with hot flashes (# of times/night)
None	1.00 (referent)	1.00 (referent)
One	1.09 (0.62, 1.92)	0.99 (0.55, 1.80)
Two	0.89 (0.49, 1.61)	0.71 (0.38, 1.33)
Three	1.01 (0.99, 3.67)	1.56 (0.78, 3.09)
Four or more	4.89 (2.29, 10.42)	4.51 (2.01, 10.11)
Change bed sheets
No	1.00 (referent)	1.00 (referent)
Yes	1.80 (1.12, 2.89)	1.63 (0.99, 2.68)#
Trouble sleeping (#/week)
None	1.00 (referent)	1.00 (referent)
1–2 times	1.03 (0.61, 1.72)	0.91 (0.53, 1.55)
3–4 times	2.56 (1.37, 4.81)	1.92 (0.99, 3.75)†
5 or more	3.76 (1.50, 9.45)	4.22 (1.53, 11.64)
Insomnia
No	1.00 (referent)	1.00 (referent)
Yes	3.34 (2.27, 4.90)	3.01 (2.02, 4.49)
Nausea
No	1.00 (referent)	1.00 (referent)
Yes	3.81 (2.23, 6.51)	3.66 (2.06, 6.50)
Headache
No	1.00 (referent)	1.00 (referent)
Yes	2.01 (1.40, 2.90)	2.01 (1.37, 2.94)
Aches and pains
	1.00 (referent)	1.00 (referent)
	2.44 (1.65, 3.61)	1.87 (1.23, 2.84)
Weakness
No	1.00 (referent)	1.00 (referent)
Yes	3.52 (2.25, 5.50)	2.94 (1.83, 4.72)
Visual changes
No	1.00 (referent)	1.00 (referent)
Yes	2.03 (1.32, 3.12)	1.71 (1.08, 2.70)
Vaginal discharge
No	1.00 (referent)	1.00 (referent)
Yes	1.78 (1.21, 2.63)	1.77 (1.18, 2.66)
Irritability
No	1.00 (referent)	1.00 (referent)
Yes	4.68 (3.05, 7.19)	4.23 (2.71, 6.58)
Muscle stiffness
No	1.00 (referent)	1.00 (referent)
Yes	1.93 (1.34, 2.79)	1.60 (1.09, 2.36)
Incontinence
No	1.00 (referent)	1.00 (referent)
Yes	2.36 (1.57, 3.53)	2.14 (1.40, 3.27)

^*adjusted for menopausal status, physical activity level, smoking status and current self-reported health status

^#p=.057

^†p=.056