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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Curr Med Chem. 2008;15(19):1863–1869. doi: 10.2174/092986708785132915

Table 4.

PGE2 levels in CSF from patients with neurologic disease

Disease CSF PGE2 Levels Reference
AD Increased levels highest in very early AD, but declined with progressive cognitive impairment [81]
Increased 5-fold in early AD [82]
ALS Increased 6-fold [83,84]
Increased 2 to 10 fold [83,84]
No increase [72]
CJD Increased 6-fold in patients with sporadic or familial forms of CJD [85]
Increased 6-fold in patients with variant CJD [86]
Ischemic stroke Increased 2-fold during initial 72 hr [87]
HAD Increased 40% in all HIV-seropositive patients and positively correlated with degree of cognitive impairment [88]