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. 2009 Jun 18;4(6):e5953. doi: 10.1371/journal.pone.0005953

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van Vuurden et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) RT-PCR of GluR1, 2 and 4 mRNA expression on primary VU-028 and VU-122 GBM cells and the established cell line U87-MG. (B) GluR2 PCR sequencing analysis. Posttransciptional RNA editing at the Q/R site in the second membrane domain (M2) of the GluR2 subunit. The glutamine (Q) codon (CAG) is substituted by an arginine (R) codon (CGG) by replacement of a single nucleotide, adenine to guanine, at position 2168. Adult and fetal brain, adult cerebellum, and glioblastoma cell line U87-MG express fully edited GluR2R (CGG). VU-028 and VU-122 express a combination of both GluR2R and unedited GluR2Q (CAG) subunits.