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Domain structure of the mutant MT1-MMPs expressed in wild type stromal keratocytes. MT1-MMP-E240A is a catalytically inactive mutant of soluble MT1-MMP and contains an Alanine in place of the active-site Glutamic acid 240. MT1-MMP-ΔTC lacks both the transmembrane domain and the cytoplasmic tail. Pro, prodomain; H, hinge region; TM, transmembrane domain; CT, cytoplasmic tail.
