Table 2.
Estimated effects for polymorphisms selected in risk factor-adjusted analyses.
| Gene symbol and dbSNP rs number | MAF | Cox regression (HR; 95%CI; p) | ||
|---|---|---|---|---|
| additive | dominant | |||
| ACE | rs1799752 | 0.445 | 1.35; 0.88–2.05; 0.17 | 1.83, 0.88–3.86, 0.11 |
| ADD1 | rs4961 | 0.208 | 0.73; 0.40–1.32; 0.29 | 0.70, 0.36–1.36, 0.30 |
| ADRB2 | rs1042713 | 0.382 | 0.89; 0.60–1.40; 0.63 | 1.09, 0.58–2.07, 0.78 |
| ADRB2 | rs1042714 | 0.423 | 1.37; 0.90–2.09; 0.14 | 1.69, 0.80–3.56, 0.17 |
| ADRB3 | rs4994 | 0.066 | 0.31; 0.15–1.36; 0.13 | 0.34, 0.08–1.40, 0.13 |
| AGTR1 | rs5186 | 0.255 | 0.97; 0.60–1.59; 0.91 | 0.97, 0.52–1.82, 0.93 |
| AGT | rs699 | 0.438 | 1.28; 0.81–2.00; 0.29 | 1.25, 0.81–2.57, 0.54 |
| APOA4 | rs675 | 0.184 | 0.97; 0.55–1.72; 0.91 | 0.90, 0.46–1.78, 0.76 |
| APOA4 | rs5110 | 0.068 | 1.24; 0.54–2.87; 0.62 | 1.31, 0.55–3.14, 0.54 |
| APOB | rs1367117 | 0.314 | 0.85; 0.52–1.40; 0.53 | 0.77, 0.41–1.44, 0.41 |
| APOC3 | rs2542052 | 0.382 | 1.03; 0.67–1.59; 0.89 | 1.01, 0.53–1.92, 0.97 |
| APOC3 | rs2854117 | 0.251 | 0.91; 0.55–1.51; 0.72 | 0.96, 0.51–1.80, 0.89 |
| APOC3 | rs2854116 | 0.368 | 1.10; 0.71–1.70; 0.68 | 1.10, 0.58–2.09, 0.78 |
| APOC3 | rs4520 | 0.266 | 1.11; 0.70–1.78; 0.66 | 0.93, 0.49–1.76, 0.83 |
| APOC3 | rs5128 | 0.098 | 0.76; 0.33–1.74; 0.51 | 0.63, 0.25–1.62, 0.34 |
| APOC3 | rs4225 | 0.368 | 1.05; 0.67–1.65; 0.83 | 0.88, 0.46–1.66, 0.68 |
| APOE | rs429358 | 0.135 | 1.05; 0.57–1.93; 0.87 | 1.08, 0.54–2.17, 0.83 |
| APOE | rs7412 | 0.088 | 1.06; 0.47–2.40; 0.89 | 1.06, 0.47–2.40, 0.89 |
| C3 | rs2230199 | 0.256 | 0.82; 0.49–1.36; 0.44 | 0.92, 0.49–1.72, 0.79 |
| C5 | rs17611 | 0.435 | 1.03; 0.64–1.66; 0.90 | 1.24, 0.60–2.55, 0.56 |
| CCL11 | rs4795895 | 0.183 | 1.38; 0.80–2.38; 0.24 | 1.66, 0.89–3.10, 0.11 |
| CCL11 | rs3744508 | 0.183 | 0.55; 0.28–1.09; 0.09 | 0.49, 0.22–1.06, 0.07 |
| CCR2 | rs1799864 | 0.088 | 2.00; 1.15–3.48; 0.014 | 2.50, 1.26–4.94, 0.008 |
| CCR5 | rs333 | 0.089 | 0.97; 0.43–2.21; 0.95 | 1.04, 0.43–2.48, 0.93 |
| CCR5 | rs1799987 | 0.457 | 0.93; 0.61–1.42; 0.75 | 0.91, 0.47–1.76, 0.77 |
| CD14 | rs2569190 | 0.448 | 0.93; 0.60–1.44; 0.75 | 0.79, 0.42–1.50, 0.47 |
| CETP | rs1800775 | 0.496 | 0.63; 0.40–0.98; 0.041 | 0.54, 0.28–1.04, 0.07 |
| CETP | rs5882 | 0.306 | 1.30; 0.82–2.06; 0.27 | 1.02, 0.54–1.91, 0.96 |
| CETP | rs708272 | 0.453 | 1.48; 0.96–2.29; 0.07 | 1.68, 0.80–3.55, 0.17 |
| CSF2 | rs25882 | 0.201 | 0.75; 0.41–1.38; 0.36 | 0.74, 0.37–1.48, 0.39 |
| CTLA4 | rs5742909 | 0.125 | 0.91; 0.45–1.86; 0.80 | 0.95, 0.45–1.99, 0.88 |
| CTLA4 | rs231775 | 0.368 | 0.82; 0.50–1.33; 0.42 | 0.70, 0.37–1.30, 0.26 |
| F5 | rs6025 | 0.137 | 1.13; 0.60–2.11; 0.71 | 1.07, 0.55–2.10, 0.84 |
| F7 | rs5742910 | 0.121 | 1.63; 0.93–2.88; 0.09 | 1.73, 0.91–3.31, 0.10 |
| F7 | rs6046 | 0.108 | 1.79; 0.99–3.23; 0.06 | 1.82, 0.94–3.51, 0.08 |
| GC | rs7041 | 0.447 | 1.56; 0.98–2.48; 0.06 | 1.35, 0.64–2.84, 0.43 |
| GC | rs4588 | 0.297 | 1.38; 0.87–2.21; 0.17 | 1.10, 0.58–2.08, 0.76 |
| GNB3 | rs5443 | 0.318 | 0.70; 0.42–1.18; 0.18 | 0.54, 0.29–1.02, 0.06 |
| ICAM1 | rs1799969 | 0.112 | 1.21; 0.62–2.38; 0.58 | 0.98, 0.45–2.14, 0.96 |
| LDLR | rs5742911 | 0.317 | 0.92; 0.58–1.46; 0.72 | 0.97, 0.51–1.84, 0.93 |
| IL1A | rs1800587 | 0.340 | 0.99; 0.60–1.63; 0.95 | 1.04, 0.54–1.98, 0.90 |
| IL1B | rs16944 | 0.350 | 0.92; 0.55–1.52; 0.74 | 1.05, 0.55–2.02, 0.87 |
| IL1B | rs1143634 | 0.229 | 1.06; 0.65–1.72; 0.83 | 1.10, 0.59–2.07, 0.76 |
| IL4 | rs2243250 | 0.165 | 0.76; 0.41–1.44; 0.40 | 0.73, 0.35–1.49, 0.38 |
| IL4R | rs1801275 | 0.201 | 0.93; 0.54–1.58; 0.78 | 0.82, 0.42–1.59, 0.56 |
| IL4R | rs1805015 | 0.166 | 1.04; 0.59–1.86; 0.88 | 0.86, 0.43–1.72, 0.66 |
| IL5RA | rs2290608 | 0.303 | 1.01; 0.61–1.70; 0.96 | 1.20, 0.63–2.25, 0.58 |
| IL6 | rs1800796 | 0.074 | 1.72; 0.87–3.40; 0.12 | 1.78, 0.88–3.59, 0.11 |
| IL6 | rs1800795 | 0.392 | 0.86; 0.54–1.37; 0.53 | 0.76, 0.40–1.44, 0.40 |
| IL9 | rs2069885 | 0.175 | 1.16; 0.66–2.02; 0.61 | 1.00, 0.50–1.96, 0.99 |
| IL13 | rs1295686 | 0.205 | 1.17; 0.70–1.96; 0.55 | 1.24, 0.66–2.35, 0.50 |
| ITGA2 | rs1062535 | 0.399 | 0.74; 0.47–1.16; 0.19 | 0.63, 0.34–1.17, 0.14 |
| ITGB3 | rs5918 | 0.140 | 0.92; 0.48–1.75; 0.80 | 0.87, 0.43–1.78, 0.71 |
| LIPC | rs1800588 | 0.223 | 1.13; 0.70–1.84; 0.61 | 1.22, 0.65–2.30, 0.54 |
| LPA | rs1853021 | 0.182 | 0.97; 0.56–1.70; 0.92 | 0.73, 0.35–1.50, 0.39 |
| LPA | rs1800769 | 0.164 | 0.75; 0.38–1.49; 0.41 | 0.70, 0.32–1.53, 0.37 |
| LPL | rs328 | 0.111 | 1.16; 0.59–2.28; 0.67 | 1.09, 0.52–2.31, 0.82 |
| LTA | rs1041981 | 0.343 | 1.08; 0.72–1.65; 0.70 | 1.02, 0.55–1.89, 0.95 |
| LTA | rs909253 | 0.344 | 1.18; 0.73–1.92; 0.51 | 1.16, 0.61–2.20, 0.66 |
| LTC4S | rs730012 | 0.271 | 0.96; 0.57–1.59; 0.87 | 0.83, 0.45–1.56, 0.57 |
| MMP3 | rs3025058 | 0.476 | 1.66; 1.10–2.49; 0.015 | 6.87, 2.12–22.30, 0.001 |
| MTHFR | rs1801133 | 0.319 | 1.26; 0.80–1.98; 0.31 | 1.12, 0.60–2.08, 0.72 |
| NOS2A | rs1137933 | 0.234 | 1.01; 0.59–1.75; 0.97 | 0.87, 0.46–1.64, 0.66 |
| NOS3 | rs1800779 | 0.379 | 0.85; 0.53–1.35; 0.49 | 0.79, 0.42–1.48, 0.47 |
| NOS3 | rs3918226 | 0.073 | 0.89; 0.36–2.22; 0.80 | 0.91, 0.36–2.33, 0.85 |
| NOS3 | rs1799983 | 0.308 | 0.82; 0.50–1.37; 0.45 | 0.70, 0.37–1.30, 0.25 |
| NPPA | rs5065 | 0.161 | 1.05; 0.60–1.82; 0.88 | 1.11, 0.58–2.13, 0.74 |
| PON1 | rs854560 | 0.375 | 0.83; 0.52–1.33; 0.44 | 1.11, 0.58–2.11, 0.76 |
| PON1 | rs662 | 0.274 | 1.79; 1.08–2.95; 0.023 | 1.78, 0.92–3.43, 0.08 |
| PON2 | rs695435 | 0.216 | 1.56; 0.96–2.54; 0.07 | 1.62, 0.86–3.04, 0.14 |
| PPARG | rs1801282 | 0.124 | 1.32; 0.67–2.59; 0.42 | 1.38, 0.69–2.79, 0.36 |
| SCGB1A1 | rs3741240 | 0.318 | 1.02; 0.64–1.63; 0.93 | 0.90, 0.48–1.68, 0.74 |
| SCNN1A | rs2228576 | 0.257 | 0.67; 0.38–1.18; 0.17 | 0.60, 0.31–1.18, 0.14 |
| SDF1 | rs1801157 | 0.213 | 0.75; 0.40–1.37; 0.35 | 0.72, 0.36–1.42, 0.34 |
| SELE | rs5361 | 0.124 | 0.71; 0.33–1.54; 0.39 | 0.74, 0.32–1.66, 0.46 |
| SELP | rs6133 | 0.118 | 1.06; 0.55–2.05; 0.86 | 1.08, 0.49–2.34, 0.85 |
| SELP | rs6131 | 0.212 | 1.35; 0.83–2.20; 0.22 | 1.78, 0.95–3.31, 0.07 |
| SERPINE1 | rs1799768 | 0.542 | 0.84; 0.55–1.28; 0.42 | 0.95, 0.46–1.94, 0.89 |
| SERPINE1 | rs7242 | 0.413 | 0.83; 0.52–1.32; 0.43 | 0.87, 0.46–1.63, 0.66 |
| TCF7 | rs244656 | 0.142 | 1.00; 0.51–1.96; 1.00 | 0.94, 0.45–2.00, 0.88 |
| TCF7 | rs5742913 | 0.116 | 1.59; 0.83–3.03; 0.16 | 1.64, 0.85–3.19, 0.14 |
| TGFB1 | rs1800469 | 0.312 | 1.08; 0.69–1.70; 0.73 | 1.36, 0.72–2.56, 0.34 |
| TNF | rs1800629 | 0.177 | 0.72; 0.38–1.35; 0.30 | 0.77, 0.38–1.54, 0.46 |
| TNF | rs361525 | 0.075 | 0.71; 0.26–1.95; 0.50 | 0.72, 0.26–2.03, 0.53 |
| VDR | rs2228570 | 0.420 | 1.03; 0.66–1.59; 0.91 | 1.09, 0.56–2.12, 0.80 |
| VDR | rs1544410 | 0.417 | 1.23; 0.78–1.94; 0.36 | 1.25, 0.64–2.47, 0.51 |
MAF, minor allele frequency; HR, hazard ratio; CI, confidence interval.
Significant results (uncorrected) from Cox regression analysis are in boldface.