Table 3.
Putative amidohydrolase superfamily members
| Database ID (GenPept GI IDs) | Method | Organism | Length | Annotation available at target selection | Verification |
|---|---|---|---|---|---|
| 7462218 | Structure-based | Thermotoga maritima | 434 | Conserved hypothetical protein | HMM |
| 7497374 | Structure-based | Caenorhabditis elegans | 818 | Hypothetical protein C44B7.10 | HMM |
| 7500805 | Structure-based | Caenorhabditis elegans | 313 | T21966 hypothetical protein F38E11.3—Caenorhabditis elegans | HMM |
| 9948434 | Structure-based | Pseudomonas aeruginosa PAO1 | 448 | Probable dipeptidase precursor (Pseudomonas aeruginosa) | HMM |
| 10173106 | Structure-based | Bacillus halodurans | 427 | BH0493 | HMM |
| 10175729 | Structure-based | Bacillus halodurans | 571 | DNA-dependent DNA polymerase beta chain | HMM |
| 13700943 | Structure-based | Staphylococcus aureus subsp. aureus N315 | 570 | DNA-dependent DNA polymerase beta chain | HMM |
| 14600641 | Structure-based | Aeropyrum pernix | 313 | 313aa long hypothetical microsomal dipeptidase | HMM |
| 14601853 | Template | Aeropyrum pernix | 394 | Hypothetical protein (Aeropyrum pernix) | HMM |
| 14602106 | Structure-based | Aeropyrum pernix | 327 | Hypothetical protein (Aeropyrum pernix) | HMM |
| 15600589 | Structure-based | Pseudomonas aeruginosa PAO1 | 325 | D82971 hypothetical protein PA5396 (imported)—Pseudomonas aeruginosa (strain PAO1) | HMM |
| 15612748 | Structure-based | Bacillus halodurans | 448 | BH0185 | HMM |
| 15614834 | Structure-based | Bacillus halodurans | 310 | Dipeptidase | HMM |
| 15791917 | Structure-based | Campylobacter jejuni subsp. jejuni NCTC | 265 | Hypothetical protein Cj0556 | HMM |
| 15805850 | Structure-based | Deinococcus radiodurans R1 | 418 | Hydrolase, putative | HMM |
| 15896580 | Structure-based | Clostridium acetobutylicum | 262 | Predicted amidohydrolase (dihydroorotase family) | HMM |
| 15898656 | Structure-based | Sulfolobus solfataricus | 314 | Microsomal dipeptidase | HMM |
| 15925570 | Structure-based | Staphylococcus aureus subsp. aureus N315 | 336 | Conserved hypothetical protein | HMM |
| 16125737 | Structure-based | Caulobacter vibrioides | 487 | Uronate isomerase (EC 5.3.1.12) (Glucuronate isomerase) (UronicDE isomerase) | HMM |
| 16126978 | Structure-based | Caulobacter vibrioides | 417 | Dipeptidase | HMM |
| 16127409 | Structure-based | Caulobacter vibrioides | 353 | Hypothetical protein | HMM |
| 16130781 | Structure-based | Escherichia coli K12 | 464 | Soluble protein involved in cell viability at the beginning of stationary phase; soluble protein involved in cell viability at the beginning of stationary phase, contains urease domain | HMM |
| 16410647 | Structure-based | Listeria monocytogenes EGD-e | 570 | lmo1231 | HMM |
| 17556402 | Structure-based | Caenorhabditis elegans | 352 | Hypothetical protein Y71D11A.3a | HMM |
| 19705473 | Structure-based | Rattus norvegicus | 336 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | HMM |
| 19911227 | Structure-based | Homo sapiens | 336 | 2-amino-3-carboxylmuconate-6-semialdehyde decarboxylase | HMM |
| 19911231 | Structure-based | Caenorhabditis elegans | 401 | 2-amino-3-carboxylmuconate-6-semialdehyde decarboxylase | HMM |
| 24379660 | Structure-based | Streptococcus mutans UA159 | 267 | conserved hypothetical protein | HMM |
| 33592291 | Structure-based | Bordetella pertussis Tohama I | 284 | Putative 2-pyrone-4,6-dicarboxylic acid hydrolase | HMM |
| 33593502 | Structure-based | Bordetella pertussis Tohama I | 341 | Putative dipeptidase | HMM |
| 39976001 | Sequence- and structure-based | Magnaporthe grisea 70–15 | 417 | Hypothetical protein | HMM |
| 42527610 | Structure-based | Treponema denticola ATCC 35405 | 371 | Dihydroorotase, putative | HMM |
| 42631159 | Structure-based | Haemophilus influenzae | 330 | Hypothetical protein | HMM |
| 51012913 | Structure-based | Saccharomyces cerevisiae | 313 | YMR262W | HMM |
| 51968376 | Structure-based | Arabidopsis thaliana | 346 | Unnamed protein product | HMM |
| 51968996 | Structure-based | Arabidopsis thaliana | 346 | Unnamed protein product | HMM |
| 55980841 | Structure-based | Thermus thermophilus HB8 | 369 | Amidohydrolase family protein | HMM |
| 60279993 | STRUCTURE-based | Pseudomonas aeruginosa | 403 | PvdM HMM | |
| 66807941 | Structure-based | Dictyostelium discoideum | 359 | Hypothetical protein | HMM |
| 66808659 | Structure-based | Dictyostelium discoideum | 322 | Hypothetical protein | HMM |
| 1065989 | Sequence-based | Bacillus subtilis subsp. subtilis str. 1 | 577 | Adenine deaminase | HMM |
| 15023784 | Sequence-based | Clostridium acetobutylicum | 570 | Adenine deaminase | HMM |
| 24636152 | Structure-based | Caenorhabditis elegans | 403 | Hypothetical protein C44B7.12 | HMM |
| 29377069 | Structure-based | Enterococcus faecalis V583 | 444 | Chlorohydrolase family protein | HMM |
| 40788915 | Structure-based | Homo sapiens | 777 | Q93075_chr3:10265710-10295706_H233R_V272I_L374P PUTATIVE DEOXYRIBONUCLEASE KIAA0218 (EC 3.1.21.-) | HMM |
| 45446932 | Sequence- and structure-based | Drosophila melanogaster | 774 | CG32626-PA, isoform A | HMM |
| 56203368 | Sequence- and structure-based | Homo sapiens | 776 | Adenosine monophosphate deaminase 1 (isoform M | HMM |
| 56203369 | Sequence-based | Homo sapiens | 780 | OTTHUMP00000059283 | HMM |
| 57230710 | Structure-based | Filobasidiella neoformans | 469 | Hydrolase, putative | HMM |
| 63055053 | Structure-based | Homo sapiens | 761 | TatD DNase domain containing 2 | HMM |
| 68250266 | Structure-based | Haemophilus influenzae | 251 | Conserved putative deoxyribonuclease | HMM |
| 429129 | Sequence-based | Saccharomyces cerevisiae | 797 | YB9Z_YEAST HYPOTHETICAL 92.9 KD PROTEIN IN SSH1-APE3 INTERGENIC REGION | Manual |
| 7293948 | Sequence-based | Drosophila melanogaster | 520 | CG5998-PA | Manual |
| 11463854 | Sequence-based | Drosophila melanogaster | 561 | Male-specific IDGF | manual |
| 14602062 | Structure-based | Aeropyrum pernix | 375 | Hypothetical protein [Aeropyrum pernix] | Manual |
| 15898896 | Structure-based | Sulfolobus solfataricus | 269 | Conserved hypothetical protein | Manual |
| 16264026 | Template | Sinorhizobium meliloti | 466 | HYPOTHETICAL PROTEIN | Manual |
| 17646150 | Sequence- and structure-based | Drosophila melanogaster | 506 | Adenosine deaminase-related growth factor C | Manual |
| 23093239 | Sequence-based | Drosophila melanogaster | 561 | CG32178-PA | Manual |
| 25009707 | Sequence-based | Drosophila melanogaster | 561 | AT05468p | Manual |
| 33593596 | Structure-based | Bordetella pertussis Tohama I | 523 | Conserved hypothetical protein | Manual |
| 40744823 | Structure-based | Aspergillus nidulans FGSC A4 | 562 | HYPOTHETICAL protein | Manual |
| 47678365 | Sequence-based | Homo sapiens | 511 | Cat eye syndrome critical region protein 1 [Homo sapiens] | Manual |
| 49116836 | Sequence- and structure-based | Xenopus laevis | 510 | Hypothetical protein | Manual |
Tables listing all amidohydrolase and enolase superfamily targets can be found at http://salilab.org/projects/enspec/ (HMM Hidden Markov Model verification)