TABLE 1.
Effect of partial hepatectomy and repeated growth selection in FahΔexon5/FahΔexon5 mice receiving PAH-deficient Pahenu2/Pahenu2 hepatocyte transplants
| Liver PAH activity in homogenate (nmol/h/mg protein) | ||||
|---|---|---|---|---|
| At partial hepatectomy (left lobe) |
After partial hepatectomy (entire liver) |
Serum phenylalanine (μM) (normal is 100–160 μM) | ||
| Mouse | At partial hepatectomy | After partial hepatectomy | ||
| 1 | 4.2 | 6.4 | 142 | 529 |
| 2 | 3.7 | None detected | 188 | 824 |
| 3 | 4.1 | None detected | 233 | 771 |
At partial hepatectomy means 74 days after hepatocyte transplant, after partial hepatectomy means 117 days after hepatocyte transplant.