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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Hypertension. 2009 Feb 2;53(3):532–538. doi: 10.1161/HYPERTENSIONAHA.108.127100

Figure 3.

Figure 3

Role of TRPV4 channels in agonist-induced vasodilation in vitro. A, Acetylcholine-induced vasodilation in mesenteric arteries of WT mice. Arteries were preincubated with in the absence and presence of L-NAME (100 µmol/L) or L-NAME plus indomethacin (10 µmol/L), and precontracted with U46619 or high K+ (60 mmol/L). * P<0.05 vs. control (n=5–14 rings from 3–5 mice). B, Acetylcholine-induced vasodilation in mesenteric arteries of WT and TRPV4−/− (KO) mice in the absence and presence of L-NAME. * P<0.05 vs. WT control; # P<0.05 vs. KO control; n=10–14 rings from 6 mice. C, Endothelium-independent vasodilation to papaverine in mesenteric arteries of WT and TRPV4−/− mice (n=4 rings from 4 mice).