Table 3.
Effect of Infarct Volume and Number on the Odds of Dementia
| Risk Factor | Adjustment Factors | |||
|---|---|---|---|---|
| Age and Sex | Age, Sex, and Number of Hemispheral Macroinfarcts | Adjusted for Sex, Age, and Hemispheral Infarct Volume | ||
| Rank | Quartiles | |||
| Hemispheral infarct volume (rank)a | 1.2b(1.1–1.3) | 1.0 (0.9–1.1) | — | — |
| Hemispheral infarct volume (quartile)a | 2.5b(1.4–4.5) | 1.0 (0.8–1.2) | — | — |
| Number of macroscopic hemispheral infarctsc | — | — | 4.6b(1.6–13) | 5.0b(1.6–17) |
Thirty-seven subjects with macroscopic hemispheral infarcts were compared with 100 subjects without infarcts using logistic regression. Age refers to age at death.
a
The odds of developing dementia based on the total hemispheral infarct volume (ranked in two separate ways) was determined controlling for age, sex, and the number of macroscopic hemispheral infarcts. The odds ratio indicates the effect of a single-step increase in the relevant volume measurement on the odds of clinical dementia.
b
Significant values, p < 0.05.
c
The effect of infarct volume (ranked by quartile or rank order) on the role of hemispheral infarct number in the odds of dementia was determined.