Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Shox2 regulates the SAN genetic program through repression of Nkx2-5. A genetic hierarchy model places Shox2 downstream of Pitx2 but upstream of Nkx2-5 in the regulation of SAN formation. Black arrows represent the up- or downregulation of expression depending on the expression or lack thereof of the upstream gene.
