Table 2.

Univariate and Multivariate analysis of factors associated with unfavorable outcome

Characteristic	Odds ratio (95% CI) (univariate)	P	Odds ratio (95% CI) (multivariate)	P
Age, yrs	1.47 (1.35–1.62)	<0.0001	1.16 (1.03–1.16)	0.01
Known diabetes	2.24 (1.23–4.11)	<0.01	0.96 (0.42–2.16)	0.9
Immunocompromised, not diabetes	2.92 (1.76–4.90)	<0.0001	1.15 (0.61–2.17)	0.7
Heart rate
< 60 bpm	2.26 (0.73–6.58)	<0.01	4.95 (1.09–22.45)	0.04
60–90 bpm	1.00 (reference)		1.00 (reference)
>90–120 bpm	1.62 (1.09–2.44)		1.23 (0.75–2.01)	0.4
>120 bpm	3.96 (2.51–6.31)	<0.001	2.44 (1.35–4.43)	0.003
Diastolic blood pressure	0.97 (0.92–1.01)	0.01	0.95 (0.90–1.01)	0.09
Glasgow Coma Scale	0.82 (0.78–0.86)	<0.001	0.87 (0.81–0.93)	<0.001
Distant focus of infection*	2.05 (1.48–2.84)	<0.0001	1.04 (0.67–1.63)	0.9
Focal neurologic deficits#	2.50 (1.80–3.48)	<0.0001	1.93 (1.28–2.90)	0.002
Blood glucose	0.87 (0.69–1.07)	0.001	0.93 (0.75–1.16)	0.5
Log platelet count	0.62 (0.50–0.76)	<0.001	0.62 (0.48–0.81)	<0.001
Log CSF leukocyte count	0.80 (0.75–0.85)	<0.001	0.80 (0.74–0.87)	<0.001
Causative organism
S. pneumoniae	7.65 (5.02–12.00)	<0.0001	4.95 (2.69–9.12)	<0.001
N. meningitidis	1.00 (reference)		1.00 (reference)
Other	3.98 (2.22–7.17)	<0.001	2.38 (1.12–5.04)	0.02

* Defined as otitis/sinusitis or pneumonia. # Defined as cranial nerve palsies, aphasia, monoparesis or hemiparesis. Bpm denotes beats per minute, CSF cerebrospinal fluid.