Table 1.

Functional profiling, positively correlated genes

Functional group	Gene set name	No. of related sets	No of members in gene set (range)	FDR q value (range)
Vesicle trafficking	Membrane fusion	2	27–52	0.022–0.026
	Vesicle transport	9	16–348	0.002–0.149
	Vesicle docking during exocytosis	1	21	0.141
Transcription/translation	Ribosome function	4	69–89	0.042–0.179
	mRNA processing	5	157–452	0.056–0.166
	Transcription from RNA pol III promoter	1	25	0.089
	mRNA catabolism	2	17–23	0.027–0.125
	translation	3	30–157	0.012–0.062
Protein transport/metabolism	Protein transport	9	17–294	0.012–0.129
	Ubiquination/proteolysis	11	133–448	0.013–0.024
	Protein folding	1	195	0.003
	Carboxylic acid metabolism	7	17–410	0.087–0.195
	Aspartate family amino acid metabolism	1	18	0.016
	Amine metabolism	2	55–57	0.142–0.152
Electron transport chain	Coenzyme metabolism	4	85–159	0.007–0.029
	Nucleotide metabolism	16	53–178	0.014–0.126
	ATP metabolism	9	36–490	0.012–0.192
	Oxidative phosphorylation	4	21–63	<0.001
	Electron transport	1	289	0.022
	Mitochondrial membrane	2	19–21	0.027–0.149
Glycolysis	Aerobic respiration	7	22–32	0.005–0.016
	Glucose metabolism	13	20–138	0.005–0.079
Oxidative stress	Response to oxidative stress	2	44–63	0.069–0.164
	Peroxisome organization and biogenesis	1	17	0.164
Cell cycle	Mitotic cell cycle	5	17–60	0.077–0.144
	Induction of apoptosis by intracellular signals	1	20	0.067
Lipid metabolism	Sphingomyelin synthesis	3	17–41	0.035–0.187
	Lipid modification	2	15–19	0.032–0.041
	Phospholipid metabolism	6	54–427	0.012–0.054
	Lipoprotein metabolism	3	29–42	0.027–0.069
	Glycerolipid metabolism	6	19–39	0.013–0.180
Others	Iron compound metabolism	6	15–52	0.002–0.053
	Autophagy	1	16	0.062
	Polysaccharide biosynthesis	1	18	0.120
	Biopolymer biosynthesis	1	18	0.128
	Telomere maintenance	1	21	0.132
	Respiratory gaseous exchange	1	17	0.188
	Regulation of Wnt receptor signalling	1	15	0.188
	Vitamin metabolism	1	48	0.188

Functional gene sets are shown which show enrichment in the list of genes positively correlated with a template showing peak expression in the 15–25 age range. Related gene sets as defined by leading edge analysis are grouped together in column 2 and the range of q values for these gene sets is indicated. Gene sets/groups of gene sets which are functionally associated but are composed of non-overlapping genes in the leading edge are indicated by headings in column 1. A full detailed list of significant gene sets can be found in Additional File 3.