. Author manuscript; available in PMC: 2010 Jul 1.

Published in final edited form as: J Hepatol. 2009 Apr 5;51(1):77–92. doi: 10.1016/j.jhep.2009.02.022

Table 4.

Immunohistochemical profile of HCC/CCC from rats subjected to the APA protocol. Percentage of cells that are positive for each marker as obtained through the analysis of 5–8 fields selected randomly from each specimen (20x objective magnification). Values presented are expressed as mean±SD (with the exception of OCT3/4, given the extreme rarity of positive cells)

ANTIGEN	TUMOR DISTRIBUTION	PERCENTAGE OF POSITIVE CELLS
GSTp	Dysplastic hepatocytes and ductular cells	94±4 HCC
GSTp	Dysplastic hepatocytes and ductular cells	79±12 CCC
OV6	Dysplastic and normal ductular cells, oval cells	15±4 HCC
OV6	Dysplastic and normal ductular cells, oval cells	96±3 CCC
CK19	Dysplastic and normal ductular cells	9±3 HCC
CK19	Dysplastic and normal ductular cells	98±2 CCC
AFP	Dysplastic hepatocytes and ductular cells, oval cells	47±14 HCC
AFP	Dysplastic hepatocytes and ductular cells, oval cells	16±9 CCC
G-CSF	Dysplastic hepatocytes, periductular and ductular tumor cells, oval cells	35±8 HCC
G-CSF		31±11 CCC
G-CSFR	Dysplastic hepatocytes, periductular and ductular tumor cells, oval cells	22±6 HCC
G-CSFR		41±16 CCC
cMet	Dysplastic hepatocytes and ductular cells	33±7 HCC
cMet	Dysplastic hepatocytes and ductular cells	28±13 CCC
OCT3/4	Very small undifferentiated tumor cells, in small clusters	<1 HCC
OCT3/4	Very small undifferentiated tumor cells, in small clusters	<1 CCC