Table 3.
Prevalence of genetic discrimination experiences reported by 233 asymptomatic people at risk for Huntington’s disease by genetic testing and test result. Values are numbers (percentages) unless stated otherwise
| Setting of discrimination | Total (n=233) | Genetically tested | Not tested (n=66) | P value of difference | ||||
|---|---|---|---|---|---|---|---|---|
| Total (n=167) | Positive test (n=83) | Negative test (n=84) | Total tested v not tested* | Positive test v negative test* | Overall† | |||
| Overall | 93 (39.9) | 71 (42.5) | 42 (50.6) | 29 (34.5) | 22 (33.3) | 0.236 | 0.042 | 0.046 |
| Insurance | 68 (29.2) | 53 (31.7) | 31 (37.3) | 22 (26.2) | 15 (22.7) | 0.202 | N/A | 0.112 |
| Family | 36 (15.5) | 31 (18.6) | 19 (22.9) | 12 (14.3) | 5 (7.6) | 0.044‡ | 0.168 | 0.034§ |
| Social | 29 (12.4) | 25 (15.0) | 17 (20.5) | 8 (9.5) | 4 (6.1) | 0.078 | 0.053 | 0.018¶ |
| Employment | 16 (6.9) | 15 (9.0) | 12 (14.5) | 3 (3.6) | 1 (1.5) | —** | 0.003†† | 0.003†† |
| Health care | 20 (8.6) | 14 (8.4) | 11 (13.3) | 3 (3.6) | 6 (9.1) | 0.802 | N/A | 0.081 |
| Public sector | 9 (3.9) | 9 (5.4) | 5 (6.0) | 4 (4.8) | 0 (0.0) | —** | —** | —** |
*Fisher’s exact test. Values are two sided.
†Positive test v negative test v not tested. Pearson’s χ2 test. Values are two sided.
N/A: post hoc comparison is not applicable as primary comparison was not significant (see corresponding overall P value).
‡P value did not reach the required significance level adjusted for false discovery rate (P≤0.014).
§Post hoc P value (positive test v not tested, P=0.013) was above the required significance level adjusted for false discovery rate (P≤0.007).
¶Post hoc P value (positive test v not tested, P=0.016) was above the required significance level adjusted for false discovery rate (P≤0.011).
**Assumptions of the χ2 test not met.
††Post hoc P values (positive test v not tested, P=0.007; negative test v not tested, P=0.016) were above the required significance levels adjusted for false discovery rate (P≤0.005 and P≤0.010, respectively).