Fig. 5.

Total flow of cholesterol from the peripheral tissues. The rates of total sterol acquisition from synthesis (Fig. 3G) and LDL-C uptake (Fig. 4G) were summed to obtain the amount of cholesterol that must leave the major peripheral organs each day (A). The total flow of cholesterol from all peripheral organs, as well as the flow from the peripheral tissues minus the brain, were also calculated (B). Each value was divided by the size of the respective cholesterol pool in that tissue to yield the daily turnover rate (C). Similarly, the mean turnover of cholesterol in all of the tissues of the periphery and in the organs of the periphery excluding the brain, was also calculated (D). The asterisk identifies those values that are significantly different (P < 0.05) from the corresponding values in the abca1^+/+ mice. Each column represents the mean ± 1 SEM.