TABLE 2.

Plasma and liver parameters after a 3-h basal (saline infusion) or hyperinsulinemic euglycemic clamp in mice fed a control or 0.025% w/w T0901317 diet for one week

	Control		T0901317
	Basal	Clamp	Basal	Clamp
Plasma triacylglycerols (mg/dl)	136.4 ± 18.7a	74.5 ± 29.3a,b	83.0 ± 70.7a,b	63.7 ± 26.3b
Plasma cholesterol (mg/dl)	69.2 ± 6.5	61.4 ± 6.2	81.7 ± 11.2	81.8 ± 10.7
Plasma NEFA (mEq/l)	0.343 ± 0.126a	NDb	0.500 ± 0.257a	NDb
Plasma insulin (ng/ml)	1.64 ± 1.06	40.7 ± 19.4	3.87 ± 1.34	19.7 ± 13.4
Liver weight (% of bodyweight)	5.4 ± 0.4	5.8 ± 0.5	5.9 ± 0.6	6.1 ± 0.5
Liver triacylglycerols (mg/g)	8.8 ± 2.4a	6.2 ± 0.9a	26.5 ± 3.0b	22.6 ± 7.6a,b
Liver cholesterol (mg/g)	2.5 ± 0.2	2.3 ± 0.1	2.3 ± 0.2	2.2 ± 0.2
Liver proteins (mg/g)	191 ± 14a,b,c	167 ± 8a,b	212 ± 9a,c	192 ± 22a,b,c
Liver MTP activity (pmol/μg protein/h)	1.14 ± 0.19	1.15 ± 0.19	1.38 ± 0.18	1.34 ± 0.12
Liver MTP activity (μmol/liver/h)	0.24 ± 0.02a,b	0.24 ± 0.06a,b	0.39 ± 0.05c	0.34 ± 0.03b,c

Food was removed from the mice 5 h before the start of the infusions. Values are averages ± SD; n = 4; ND, not detectable; values that do not share a superscript symbol are significantly different.