TABLE 4.
Plasma apoA-I and lipid levels
| AAVa | ApoA-I (mg/dl) | HDL Cholesterol (mg/dl) | Total Cholesterol (mg/dl) | Cholesteryl Ester (%) | Phospholipids (mg/dl) | Triglycerides (mg/dl) |
|---|---|---|---|---|---|---|
| WT apoA-I | 154 ± 4 | 80 ± 13 | 104 ± 13 | 73 ± 2 | 199 ± 23 | 41 ± 5 |
| apoA-IMilano | 121 ± 9b | 31 ± 2b | 44 ± 14b | 65 ± 2b | 139 ± 11b | 61 ± 22 |
| R173S apoA-I | 115 ± 10b | 48 ± 5b | 63 ± 8b | 71 ± 3 | 133 ± 17b | 40 ± 14 |
| R173K apoA-I | 147 ± 16 | 81 ± 13 | 105 ± 18 | 72 ± 2 | 190 ± 30 | 35 ± 9 |
| LacZ | 0 ± 0b | 14 ± 1b | 20 ± 3b | 66 ± 4b | 69 ± 11b | 31 ± 4 |
a
Respective AAV injected into apoA-I−/− mice with a dose of 1.0 × 1012 viral particles. All data taken from week 6 postinfection (except percentage cholesteryl ester, week 10) and represent a mean ± SD (n = 5).
b
P < 0.001 compared with WT.