TABLE 5.
Lipid compositions of HDL in mice expressing human ApoA-I variants
| HDLa | Phospholipid:apoA-I (mol:mol) | Free Cholesterol:apoA-I (mol:mol) | Cholesteryl Ester:apoA-I (mol:mol) | Triglyceride:apoA-I (mol:mol) |
|---|---|---|---|---|
| WT | 70 ± 24 | 9 ± 1 | 26 ± 9 | 1 ± 1 |
| Milano | 66 ± 14 | 11 ± 1 | 30 ± 10 | 2 ± 2 |
| R173S | 59 ± 13 | 6 ± 2 | 21 ± 4 | 1 ± 1 |
| R173K | 64 ± 11 | 7 ± 1 | 27 ± 9 | 1 ± 1 |
a
Respective AAV injected into apoA-I−/− mice with a dose of 1.0 × 1012 viral particles. All data taken from week 6 postinfection and represent a mean ± SD (n = 3–7).