TABLE 2.

Effect of SCP-2 overexpression and cholesterol-rich diet on serum levels of total cholesterol, phospholipids, and bile acids

	WT		SCP-2 Overexpressor
Lipid	Control	Cholesterol	Control	Cholesterol
	Female Mice
Total cholesterol	3.5 ± 0.5	2.3 ± 0.2	4.3 ± 0.4	3.3 ± 0.2@
Phospholipid	2.3 ± 0.3	2.2 ± 0.3	3.7 ± 0.2*	2.1 ± 0.2**
Bile acid	22 ± 4	22 ± 3	40 ± 0.6*	27 ± 5**
	Male Mice
Total cholesterol	5.1 ± 0.2	5.0 ± 0.3	5.6 ± 0.1	5.3 ± 0.4
Phospholipid	4.5 ± 0.1	3.7 ± 0.2*	4.7 ± 0.1	3.9 ± 0.2**
Bile acid	23 ± 3	25 ± 4	41 ± 6*	20 ± 2**

Concentrations of serum total cholesterol (mmol/L), phospholipids (mmol/L), and bile acid (μmol/L) were determined as described in Materials and Methods. Values represent means ± SE, n = 3–8. * Indicates P < 0.04 compared with WT mice on the control diet. ** Indicates P < 0.05 compared with SCP-2-overexpressing mice on the control diet. The “at” symbol (@) indicates P < 0.01 compared with mice on the cholesterol-rich diet.